Pharmacokinetic interaction between imatinib and tacrolimus in rats

Last Updated: Friday, July 17, 2026

This study investigated the interaction between imatinib and tacrolimus in rats. Results showed that imatinib increased tacrolimus concentrations. After multiple doses, tacrolimus reduced imatinib concentrations, suggesting drug-drug interactions. These findings highlight the need for caution when co-administering these medications.

Current Drug Metabolism

medRxiv

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